Chapter 1 provides ethnographic detail about entering and being confined to a Phase I clinic. It provides a sense of place: what one such clinic looks like and how it operates as well as the clinic’s social world, including the camaraderie and conflicts among healthy volunteers. The project methods are described, including how access to the six clinics was gained for the study, how field work was conducted, and the demographic information for the research staff and healthy volunteers who were included in the study.